BioWare's first all orginal RPG was Jade Empire, a action-themed game with Asian influences. It was first release for the original Xbox in 2005 and later for the PC in 2007. While BioWare team members have talked about doing a sequel to Jade Empire some day there is now evidence that Jade Empire 2 was more than just a thought experiment.
The LinkedIn profile for game designer Rafael Brown, now working at id Software, lists Jade Empire 2 as a game he worked on but was unreleased. Again, BioWare has never officially announced plans for a Jade Empire 2 but it appears that there were at least some progress made on the sequel.