The podcast has info from 2K Australia's producer Jake Drobowiecki who talks about their work on the PC port. That includes changing the UI and HUD in the game to work with a mouse and keyboard (in fact, they made the decision not to support controllers at all in the PC version). They also talk about supporting Nvidia's 3D Vision technology, having some visual extras for the DirectX 10 users (it also supports DirectX 9) and more. The feature also has some PC specific screenshots from the game.
In related news, Best Buy is planning to hold midnight openings on February 9 for the launch of BioShock 2. If you want to grab your copy in the middle of the night you can do so at these locations.
Gallery: BioShock 2 PC Screenshots