Science Girls! is the story of a typical high school that's under attack by plant-like aliens. You know: Mondays. You play the role of you, a teenaged girl wearing a mask for no good reason other than what you tell your compatriot in the Science Club: "It's an experiment." Each girl in the Club has her own specialty; yours is Psychology. So apparently the experiment is on everyone else.

The game begins with you at school, talking with another Science Club member. Jennifer is the Biology specialist, and your interaction with her is pretty funny. The two of you bicker a bit before hearing screams coming from outside, and go to the windows to find a number of creatures that look like vegetables attacking the faculty. It's time for the girls of the Science Club to go to the rescue!

You and Jennifer decide to go from floor to floor to look for those in need of assistance. You start on the 5th floor, and you can't get down to lower levels until you've gone through each room on the floor. Most of the rooms are empty except for an alien to attack. Once the attack begins, the graphic changes from the room in question to an isometric view of a bare grey floor, with your team on the left and the monster on the right. Even further, you and Jennifer change to tiny chibi versions of yourselves, and it's on.

This is where RPG fans will feel right at home. Combat is turn-based; typically, your team will attack first, then the aliens, but sometimes it's staggered. Everyone attacks until either side is defeated; each team member gets a turn.

A turn consists of choosing from one of five options in your character's menu: Punch, Defend, Item, Flee, Special. Each character has these options, regardless of any particular specific abilities they might individually have. Choosing Punch requires the expenditure of one SP, a unit that measures how many actions a character can take. Why it's "SP" rather than "AP" is beyond my understanding. The other metric is HP, which measures your character's health.